Endocrine Abstracts

In COVID-19 patients the occurrence of low T3 serum values is associated with disease severity and death, but hormonal substitutive replacement is still debated. Clinical trials reported so far failed to demonstrate clear beneficial effects of T3, T4 or both treatments. With the aim to analyze the peripheral effects of the acute deficiency of T3 in blood, we analyzed body fluid composition in 74 COVID-19 patients, admitted to our University Hospital during the last pandemic wa...

We have previously shown that Low T3 syndrome is associated with serum markers, radiologic and clinical scores of COVID-19 severity and it can be considered as a novel biomarker of the severity of the disease (Endocrine Abstracts 2020, 70 AEP1091). With the aim to analyze the mechanisms that are at the basis of this condition as well as the pathways involved, we applied an integrative approach of multi-omics data. We performed: i) multiplex cytokine assay, using the B...